A tumor suppressor role for PP2A-B56α through negative regulation of c-Myc and other key oncoproteins
نویسندگان
چکیده
منابع مشابه
The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model
Protein phosphatase 2A (PP2A) is a ubiquitously expressed Serine-Threonine phosphatase mediating 30-50% of protein phosphatase activity. PP2A functions as a heterotrimeric complex, with the B subunits directing target specificity to regulate the activity of many key pathways that control cellular phenotypes. PP2A-B56α has been shown to play a tumor suppressor role and to negatively control c-MY...
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ژورنال
عنوان ژورنال: Cancer and Metastasis Reviews
سال: 2008
ISSN: 0167-7659,1573-7233
DOI: 10.1007/s10555-008-9128-9